Drug Targets
S.No. Target  Function 
1 GDNF Receptor that Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla
2 PARK2 Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene 
3 SNCA Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores
4 SLC18A2 Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles.
5 SLC6A2 Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) Can also mediate sodium- and chloride-dependent transport of dopamine
6 SLC6A3 Mediates sodium- and chloride-dependent transport of dopamine.Also mediates sodium- and chloride-dependent transport of norepinephrine