Parkinson's disease (PD) is a progressive neurological disorder characterized by the degeneration of dopaminergic neurons in the brain, leading to motor symptoms such as bradykinesia, tremor, and rigidity. In addition to motor symptoms, PD can also manifest with non-motor symptoms like cognitive impairment and autonomic dysfunction. As the disease progresses, individuals may experience significant disability and a decline in quality of life. Treatment approaches for PD typically involve medications to manage symptoms, such as levodopa/carbidopa, as well as surgical interventions like deep brain stimulation in advanced cases.
Effective therapy of parkinson disease requires maximum therapeutic efficacy, with minimal undesirable effects to ensure a good quality of life for patients. The carefully selected drug targets with combination of therapeutic interventions provides patients with the opportunity to derive maximum benefit from therapy while minimizing or eliminating recurrence, resistance and toxic effects, as well as ensuring that patients have a good quality of life. This database provides drug targets for Parkinsons disease treatments and various novel leads that had been made available.