SVIMS Bioinformatics Infrastructure Facility, BIF

Welcome to SVIMS Bioinformatics Centre - BIF, Centre for Advanced Research (CfAR), SVIMS University, Tirupati.; Supported by Department of Biotechnology, Ministry of Science and Technology, Govt. of India.

Website designed by: Dr. Amineni Umamaheswari and D. Pradhan

Updates

8th National Seminar on Bioinformatics

Database on Infective Endocarditis

Database on Leptospira Drug targets

Database on Drug Targets and Vaccine Candidates of Bacterial Menigitis

Database on Cancer Drug Targets and Inhibitors

Database on Alzheimer's Disease Targets

Database on Atherosclerosis Disease Targets

Database on in silico trials against MMPs in breast cancer

Database on Mycobacterium tuberculosis target identification, drugs and vaccine design

Publications

2018

International Research Journal of Pharmacy: Synthesis, molecular docking studies and antimicrobial activity of Mannich bases of thiazolidine-2,4- diones.

Frontiers in Pharmacology: In silico Prediction, Characterization, Molecular Docking, and Dynamic Studies on Fungal SDRs as Novel Targets for Searching Potential Fungicides Against Fusarium Wilt in Tomato.

International Journal of Pharmacy and Biological Sciences: Synthesis, molecular docking studies and antimicrobial activity of substituted cinnamides

Microbial Pathogenesis: An in silico study: Novel targets for potential drug and vaccine design against drug resistant H. pylori

Letters in Drug Design & Discovery: Synthesis, Biological Evaluation and Docking Studies of N-(2-benzamido feruloyl) Aryl Hydrazone Analogues

International Journal of Basic & Clinical Pharmacology: Analgesic activity of Alpinia galanga extract in mice models and TNFalpha receptor computational docking analysis on its leads with pharmacokinetics prediction

2017

Journal of Proteins and Proteomics: Design and validation of novel antagonists of stromelysin-1 (MMP-3) through core hopping, ROC metrics and molecular dynamics simulations

Biochemistry and Analytical Biochemistry: E-Pharmacophore Model Assisted Discovery of Novel Antagonists of nNOS

2016

Journal of Informatics and Data Mining: Identification of Effectual Inhibitors against Human Insulin like Growth Factor Binding Protein-2

The Journal of Clinical and Scientific Research: Molecular docking and dynamic studies of human growth factor receptor bound protein (Grb) 2 insights to identify novel inhibitors

The Journal for Endocrinology and Metabolism: Screening the estrogenic potency of nonylphenol in rats: in vivo and in silico approaches

Journal of Proteomics & Bioinformatics: Inhibitor Design for VacA Toxin of Helicobacter pylori

International Journal of Computational science, Mathematics and Engineering: Identification of novel antagonists for DNA processing chain A (DprA) of H. influenza.

International Journal of Computational science, Mathematics and Engineering: Potent antagonist of alpha-2, 3-sialyltransferase of Neisseria meningitides.

International Journal of Computational science, Mathematics and Engineering: Ligand based 3D-QSAR approach of EGFR.

International Journal of Computational science, Mathematics and Engineering: Identification of novel thymidylate synthase therapeutics for treatment of H.pylori.

Journal of Receptors and Signal Transduction: Inhibitor design against JNK1 through e-pharmacophore modeling docking and molecular dynamics simulations.

Online Journal of Bioinformatics: In silico agonist for human extracellular superoxide dismutase SOD3.

2015

Biochemistry & Analytical Biochemistry: E-Pharmacophore Based Virtual Screening to Identify Agonist for PKA-Cα.

Journal of Receptors and Signal Transduction: E-pharmacophore-based virtual screening to identify GSK-3β inhibitors.

Biochemistry & Analytical Biochemistry: Identification of Putative Drug Targets and Vaccine Candidates for Pathogens Causing Atherosclerosis.

International Journal of Scientific and Engineering Research: Identification of Novel Inhibitors for Inositol Mono-phosphatase of Staphylococcus aureus through Virtual Screening.

International Journal of Scientific and Engineering Research: Discovery of Potent Inhibitors against GTP Pyrophosphokinase of Neisseria meningitidis Serogroup B.

International Journal of Scientific and Engineering Research: Identification of Novel Inhibitor Molecules for Choloylglycine Hydrolase of Enterococcus faecalis.

International Journal of Scientific and Engineering Research: Prediction of Novel Inhibitors against Exodeoxyribonuclease І of H. influenzae through In Silico Approach.

Interdisciplinary Sciences: Computational Life Sciences: In silico approach to support that p-nitrophenol monooxygenase from Arthrobacter sp. strain JS443 catalyzes the initial two sequential monooxygenations.

2014

Sugar Tech: A Sugarcane Germplasm Database.

Synthesis, biological evaluation and molecular docking studies of N-(α-acetamidocinnamoyl) aryl hydrazone derivatives as antiinflammatory and analgesic agents.

Genome-based approaches to develop epitope-driven subunit vaccines against pathogens of infective endocarditis.

Para-(benzoyl)-phenylalanine as a potential inhibitor against LpxC of Leptospira spp.: Homology modeling, docking and molecular dynamics study.

2013

Identification of potent inhibitors for β-secretase through structure based virtual screening and molecular dynamics simulations.

Molecular modeling, docking and dynamics studies of biotin carboxyl carrier protein of acetyl-CoA carboxylase to discover potential inhibitors..

Structure-based virtual screening towards identification of potential FabH inhibitors.

Discovery of potent KdsA inhibitors of Leptospira interrogans through homology modeling, docking, and molecular dynamics simulations.

T-cell vaccine design for Streptococcus pneumoniae : an in silico approach.

Genome-based approaches to develop epitope-driven subunit vaccines against pathogens of infective endocarditis.

In Silico drug targets for infectious endocarditis.

Computational approaches to identify common subunit vaccine candidates against bacterial meningitis.

2012

Molecular docking of a beta-2-microglobulin drug target.

Homology model of sugarcane soluble acid invertase.

Docking and molecular dynamics simulations studies of human protein kinase catalytic subunit alpha with antagonist.

Docking studies towards exploring lead molecules against binding pocket of yellow fever virus envelope protein.

2011

Docking and molecular dynamic simulations of Legionella pneumophila MurB reductase for potential inhibitor design.

Computational analysis of K-Hefutoxin interaction with Kv channels and L-carnitine molecule for scorpion envenomation.

Computer aided subunit vaccine design against pathogenic Leptospira serovars.

Homology Modeling and Active Site Analysis of MurB Reductase: A Potential Drug Target of Legionella pneumophila.

Docking studies towards exploring lead molecules against binding pocket of yellow fever virus envelope protein.

Virtual human MEK1 protein inhibitors catechin and gw8510.

Docking studies towards exploring lead molecules against binding pocket of yellow fever virus envelope protein.

2010

In silico identification of common putative drug targets in Leptospira interrogans.

Virtual screening for potential inhibitors of homology modeled Leptospira interrogans MurD ligase.

Identification of potential Leptospira phosphoheptose isomerase inhibitors through virtual high-throughput screening.

2009

In silico approach for future development of subunit vaccines against Leptospira interrogans serovar Lai.

2008

In silico Putative Drug targets in Leptospira interrogans and Homology Modeling of UDP-N-acetylglucosamine 1-carboxyvinyltransferase Mur A.

No. of Visitors

SVIMS Bioinformatics Centre, BIF, Dept. of Bioinformatics, SVIMS University,Tirupati-517507